Download Casarett & Doull's Toxicology The Basic Science of Poisons, by Curtis Klaassen PDF


By Curtis Klaassen

The main relied on all-in-one assessment of the biomedical and environmental elements of toxicology--NOW extra whole, updated, and in complete color
The worlds prime and so much authoritative textbook on poisons has extra to supply students,toxicologists, and pharmacologists than ever earlier than. Now in complete colour, and punctiliously revised, the 8th variation of Casarett & Doulls TOXICOLOGY: the fundamental technology of toxins not just gives you a entire evaluate of the basic elements of toxicology, it deals the main updated, revealing, and in-depth examine the systemic responses of poisonous substance on hand anywhere.
Combined with the newest considering by means of the fields finest students plus reliable assurance of common ideas, modes of motion, and chemical-specific toxicity, this landmark textual content keeps to set the normal for toxicology references.
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretation of the elemental parts of toxicology featured through the text
- improved tables, illustrations, and different visuals are up to date with state of the art criteria that makes this variation much more present and relevant
- NEW CHAPTERS contain «Toxic results of energy» and «Toxic results of Nanoparticles»

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Additional info for Casarett & Doull's Toxicology The Basic Science of Poisons, Eighth Edition

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This provides an interesting example of how a highly toxic drug with selectivity toward a specific population (pregnant women) can be used relatively safely with proper precautions. Following its approval for therapeutic use in 1998, a program was established that required all clinicians, pharmacists, and patients who receive thalidomide to enroll in a specific program (System for Thalidomide Education and Prescribing Safety [STEPS]). The population at risk for the potential teratogenic effects of thalidomide (all women of childbearing age) was required to use 2 forms of birth control, and also have a negative pregnancy test within 24 hours of beginning therapy, and periodically thereafter.

As the field of toxicology has matured and its influence on societal issues has increased, so has the need for the profession to make a commitment to examine the ethical, legal, and social implications of research and practice of toxicology. General Characteristics of the Toxic Response One could define a poison as any agent capable of producing a deleterious response in a biological system, seriously injuring function or producing death. This is not, however, a useful working definition for the very simple reason that virtually every known chemical has the potential to produce injury or death if it is present in a sufficient amount.

Line A) A chemical with very slow elimination (eg, half-life of 1 year). (Line B) A chemical with a rate of elimination equal to frequency of dosing (eg, 1 day). (Line C) Rate of elimination faster than the dosing frequency (eg, 5 hours). Blue shaded area is representative of the concentration of chemical at the target site necessary to elicit a toxic response. For many chemicals, the toxic effects that follow a single exposure are quite different from those produced by repeated exposure. For example, the primary acute toxic manifestation of benzene is CNS depression, but repeated exposures can result in bone marrow toxicity and an increased risk for leukemia.

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