Download Cancers in People with HIV and AIDS: Progress and Challenges by Robert Yarchoan PDF

Nonfiction 12

By Robert Yarchoan

ISBN-10: 1493908588

ISBN-13: 9781493908585

The organization among AIDS and melanoma used to be well-known from the start of the AIDS epidemic, whilst the looks of Kaposi sarcoma in a cluster of younger males was once one of many first symptoms of this new disorder. It used to be quickly well-known that AIDS used to be brought on by an infection with a unique virus (HIV) and that AIDS sufferers are at risk of enhance a couple of “AIDS-defining” cancers: Kaposi sarcoma, lymphoma, and cervical melanoma. the improvement of potent blend anti-HIV treatment beginning round 1996 switched over AIDS from a dying sentence to a achievable illness and ended in dramatic shifts within the epidemic. As this treatment was once in a position to enhance immune functionality in sufferers, the occurrence of such a lot “AIDS-defining” cancers lowered. there's a false impression, even though, that AIDS has long gone away. actually, as AIDS sufferers reside longer, the variety of AIDS sufferers has greater than doubled within the usa considering the fact that 1996, and the AIDS inhabitants total has elevated in age. additionally, as AIDS sufferers are much less more likely to die of different issues, melanoma is coming to the vanguard as some of the most universal factors of dying in areas the place AIDS medicines are generally to be had. furthermore, the 3 “AIDS-defining” cancers at the moment are taking a again seat to a few different HIV-associated cancers, comparable to Hodgkin lymphoma, lung melanoma, and anal melanoma. within the constructing global, AIDS-associated cancers are an enormous public illness, and in a few areas of sub-Saharan Africa, Kaposi sarcoma is the most typical tumor in men.

In contemporary years, there was an enormous elevate in our realizing of HIV-associated cancers. We now understand, for instance, that almost all are as a result of different viruses and that the most position of HIV and immunodeficiency is to supply a supportive atmosphere for the viruses to multiply and for the cancers to advance. yet there stay a few unanswered questions and a necessity for more desirable prevention and remedy. within the 28 chapters of this booklet, written by way of probably the most popular specialists during this box, we current updated info at the cancers linked to HIV an infection. The chapters hide the epidemiology of those cancers, their pathogenesis, their scientific presentation, and their remedy. The publication may be of price to physicians, different doctors, scholars, and researchers with an curiosity in AIDS, viral-associated cancers, or HIV-associated malignancies.


1. HIV-associated Cancers: Overview

Robert Yarchoan, Thomas Uldrick, Mark Polizotto

2. Epidemiology of AIDS-defining Malignancies

William A. Blattner and Rebecca G. Nowak

3. Epidemiology of non-AIDS Defining Malignancies

Andrew E. Grulich

4. HIV Cancers in Resource-Limited Regions

Sam M. Mbulaiteye

5. Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Blossom Damania and Dirk P. Dittmer

6. Epstein Barr Virus (EBV)

Lindsey Hutt-Fletcher

7. Human Papillomavirus (HPV)

Zhi-Ming Zheng

8. Merkel mobilephone Polymavirus (MCV)

Nicole Fischer and Adam Grundhoff

9. Presentation and Pathogenesis of Kaposi's Sarcoma

Corey Casper

10. administration of Kaposi's Sarcoma

Susan E. Krown

11. Presentation and Pathogenesis of HIV Lymphomas

Richard F. Little, Stefania Pittaluga, Kieron Dunleavy

12. Diffuse huge B-Cell Lymphoma

Neel ok. Gupta and Lawrence D. Kaplan

13. Burkitt and Burkitt-Like Lymphoma

Kishor Bhatia and Sam M. Mbulaiteye

14. basic Effusion Lymphoma

Giovanna Tosato

15. AIDS-related relevant worried method Lymphoma

Jan Davidson-Moncada and Thomas Uldrick

16. Plasmablastic and different Lymphomas

Huan-You Wang, Ida Wong-Sefidan, Erin Reid

17. Hodkin Lymphoma

Michele Spina, Rosanna Ciancia, Accursio Augello

18. Multicentric Castelman Disease

Mark N. Polizzotto, Thomas S. Uldrick, Robert Yarchoan

19. Cervical Cancer

Elizabeth A. Stier

20. Anal Cancer

Joel Palefsky

21. different HPV-Associated Cancers

Kristina R. Dahlstrom and Erich M. Sturgis

22. Lung melanoma in HIV Infection

Deepthi Mani and David M. Aboulafia

23. Hepattocellular Carcinoma in HIV-positive Patients

Massimiliano Berretta, Paolo De Paoli, Umberto Tirelli, Bruno Cacopardo

24. Merkel phone Carcinoma and different HIV-associated pores and skin Cancers

Nathalie C. Zeitouni adn Bethany Lema

25. Conjuctival Carcinoma

Kenneth O. Simbiri and Erle S. Robertson

26. Malignancies in youngsters with HIV Infection

D. Cristina Stefan

27. cART and Supportive Care

Ronald T. Mitsuyasu

28. Stem phone Transplantation

Christine Durand and Richard Ambinder

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Additional resources for Cancers in People with HIV and AIDS: Progress and Challenges

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Blood. 2003;101(12):4653–9. Lowy DR, Schiller JT. Prophylactic human papillomavirus vaccines. J Clin Invest. 2006;116(5): 1167–73. Martin JN. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and Kaposi sarcoma. Adv Dent Res. 2011;23(1):76–8 [Review]. Martin DF, Kuppermann BD, Wolitz RA, Palestine AG, Li H, Robinson CA. Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group. N Engl J Med. 1999;340(14):1063–70. Martinez-Maza O, Breen EC.

H. pylori eradication is frequently associated with complete remission of the MALT lymphoma (IARC 2009). Merkel Cell Carcinoma Merkel cell carcinoma (MCC) is a rare but very aggressive skin cancer. In people with HIV, MCC occurs about 13-fold more commonly than in the general population, and it also occurs at greatly increased rates in organ transplant recipients and other immunosuppressed states including chronic lymphocytic leukemia. In 2008, it was discovered that a polyomavirus, now termed Merkel cell polyomavirus, is clonally integrated in Merkel cell carcinoma tissue (Feng et al.

Yarchoan R, Tosato G, Little RF. Therapy insight: AIDS-related malignancies - the influence of antiviral therapy on pathogenesis and management. Nat Clin Prac Oncol. 2005;2(8):406–15. Yarchoan R, Pluda J, Wyvill K, Aleman K, Rodriguez-Chavez IR, Tosato G, et al. Treatment of AIDS-related Kaposi’s sarcoma with interleukin-12: Rationale and preliminary evidence of clinical activity. Crit Rev Immunol. 2007;27(5):401–14. Ziegler JL, Bluming AZ, Morrow Jr RH, Cohen MH, Fife Jr EH, Finerty JF, et al.

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