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Toxicology

By Jim E. Riviere

ISBN-10: 082472979X

ISBN-13: 9780824729790

Highlighting the most recent advances in molecular biology, mathematical modeling, quantitative danger evaluate, and biopharmaceutical improvement, this reference offers how present medical functions and strategies influence and revolutionize mainstream toxicological learn. providing findings from disciplines that may influence the way forward for toxicology in future years together with proteomics, toxicogenomics, and metabonomics, this expertly conceived consultant explores toxicological problems with specific global curiosity, comparable to toxicity of nanomaterials, army jet fuels, and genetically-modified meals.

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Springer Series in Information Sciences. Vol. 30. Berlin: Springer, 2001:501. 43. Tamayo P, Slonim D, Mesirov J, et al. Interpreting patterns of gene expression with selforganizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci USA 1999; 96:2907–2912. 44. Steiner G, Suter L, Boess F, et al. Discriminating different classes of toxicants by transcript profiling. Environ Health Perspect 2004; 112:1236–1248. Toxicogenomics: Gene Expression Analysis and Computational Tools 23 45.

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Each frame illustrates the same region of the 2-DE gel pattern, containing calreticulin precursor (upper left in each frame) and hsp60 (middle right), among others. Approximately 1100 protein spots were matched in each pattern, with 415 spots matched in every pattern. Abbreviation: 2-DE, two-dimensional electrophoresis. Source: From Ref. 24. ’’ Its use (or misuse) here is intended as a point of emphasis with respect to the vast dynamic range of protein expression and our desire to ‘‘sharply focus’’ on and accurately analyze expression of the least abundantly expressed protein alongside the most abundant protein, and everything in between.

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