Download Biologic Markers in Immunotoxicology by National Research Council, Division on Earth and Life PDF

Toxicology

By National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Biologic Markers, Subcommittee on Immunotoxicology

ISBN-10: 0309043891

ISBN-13: 9780309043892

Are environmental pollution threatening the human immune procedure? Researchers are swiftly impending definitive solutions to this question, simply by biologic markers - subtle review instruments that may revolutionize detection and prevention of convinced ailments. This quantity, 3rd in a chain on biologic markers, makes a speciality of the human immune procedure and its reaction to environmental toxicants. The authoring committee offers path for carrying on with improvement of biologic markers, with innovations for utilizing markers to immunotoxicology in people and urged outlines for scientific and box reports. This complete, updated quantity should be important to experts in toxicology and immunology and to biologists and investigators considering the advance of biologic markers.

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The nonspecific effects of pregnancy on the immune system include those mediated by hormones such as estrogen, which is largely immunosuppressive. , 1987). The specific effects of pregnancy involve the maternal immune response to paternally derived antigens of the fetus and placenta. Placental antigens (mostly from the major histocompatibility complexes) can evoke antibody, cellular, and morphologic responses by the maternal immune system (Gill, 1985). Humoral responses to antigens of the human fetoplacental unit include antibody to antigens of the ABO and Rh blood groups.

FIGURE 2-2 A model of the competent immune system depicting normal interrelations of the major components. The normal function of the immune system involves a complex sequence of cellular and biochemical events. Opportunities for dysfunction can occur at any point in the system and can result in a variety of immunologic effects from hypersensitivity to immunodeficiency (Twomey, 1982). MECHANISMS OF CHEMICALLY INDUCED IMMUNE DISEASE Exposure to immunotoxicants can cause immunologic suppression, resulting in altered host resistance.

Please use the print version of this publication as the authoritative version for attribution. html INTRODUCTION 15 exposed populations to exhibit markedly different effects (Hulka and Wilcosky, 1988). However, in other cases, it can be difficult to distinguish between susceptible and nonsusceptible individuals, either because of multiple interactive influences and genetic polymorphisms or because of difficulties with measuring susceptibility factors. Potential sources of normal variability in markers of immunotoxicity can be the result of genetic, environmental, or biorhythmic influences other than the specified events that are the object of study.

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