Download Biochemistry and Molecular Biology of Antimicrobial Drug by Trevor J. Franklin, George Alan Snow PDF
By Trevor J. Franklin, George Alan Snow
The topic is one among significant curiosity in simple microbiology and infectious illnesses and the booklet is a recognized vintage.
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Additional info for Biochemistry and Molecular Biology of Antimicrobial Drug Action
K . CH s 13 34 NOCH3 Representative penicillins and cephalosporins. 4 Antibiotics tliat inhibit peptidoglycan biosynthesis property. g. 13) are much less susceptible to attack by p-lactaniase, an enzyme which converts penicillin to the antibacterially inactive peniciiloic acid and gives rise to the commonest fomi of resistance to penicillin (Chapter 9). 14), which is a p~lactam itself but without useful antibacterial activity, provided an opportunity to coadminister this agent with p-lactamase~ o o [i n HOOCCHCHjCHjCNHCHCNH.
The second residue is always D-glutamic acid, linked through its Y~carboxyl group, and the fourth is invariably D-alanine. The peptidoglycan from Staphylococcus aureus (type A2) is characteristic of many Gram-positive cocci. Peptidoglycans of this group, and the related types A3 and A4, have similar tetrapeptide side chains but vary in their bridging groups. The amino acids in the bridge are usually glycine, alanine, serine or threonine, and the number of residues can vary from one to five. In type Al peptidoglycans, the L-lysine of the type 11 peptide side chain is usually replaced by meso~2,6,~ diaminopimelic acid, and there is no bridging group.
16). This enzyme, abbreviated to InhA, catalyzes the NADH-dependent reduction of the 2-franj~enoyl-acyl canier protein (ACP), an essential reaction in the elongation of fatty acids. Longchain substrates containing between 16 and 18 carbon atoms are preferentially used by InhA, an observation which implicates the reductase in the biosynthesis of the mycolic acids. Inhibition of the biosynthesis of mycolic acids therefore disrupts the assembly of the mycolyl-arabinogalactan-peptidoglycan complex and causes the loss of cell viability.