Download Basic and Clinical Pharmacology, 11th Edition (LANGE Basic by Bertram Katzung, Susan Masters, Anthony Trevor PDF

Toxicology

By Bertram Katzung, Susan Masters, Anthony Trevor

ISBN-10: 0071604057

ISBN-13: 9780071604055

The main relied on and up to date pharmacology textual content in drugs -- thoroughly redesigned to make the training procedure much more attention-grabbing and effective A Doody's middle name crucial buy for 2011! five celebrity Doody's assessment! "This is the main universal textbook for instructing pharmacology to healthiness pros. This eleventh variation is much improved to any prior editions....The authors' targets are to supply an entire, authoritative, present, and readable textbook of pharmacology for college students in healthiness sciences. Testimony to their luck is the common use of this paintings as required textbook for pharmacology classes worldwide. This publication is used commonly via hundreds of thousands of scientific, pharmacy, podiatry, nursing, and different overall healthiness professions scholars to check pharmacology. Likewise, it is still a beneficial source for citizens and working towards physicians....I proceed to take advantage of this booklet as a required source for all classes that I educate to scientific, nursing, and allied wellbeing and fitness scholars. it truly is authoritative, readable, and supported through a number of studying tools."--Doody's overview carrier equipped to mirror the syllabi in Pharmacology classes, simple & scientific Pharmacology covers the entire vital strategies scholars want to know in regards to the technology of pharmacology and its software to medical perform. it really is stated around the world because the field’s most present, authoritative, and accomplished textbook. To be as clinically suitable as attainable, the booklet contains a robust specialize in the alternative and use of gear in sufferers and the tracking in their results. assurance that spans each vital element of clinical pharmacology: uncomplicated rules Autonomic medications Cardiovascular-Renal medications medicines with very important activities on delicate Muscle medicinal drugs that Act within the valuable apprehensive process medications Used to regard ailments of the Blood, irritation, and Gout Endocrine medicines Chemotherapeutic medicines Toxicology NEW to this variation: Full-color presentation, together with three hundred+ illustrations Case reports introduce medical difficulties in lots of chapters Drug precis tables for key details in comparative context Descriptions of vital newly published medications, together with new immunopharmacologic brokers multiplied insurance of normal options on the subject of newly stumbled on receptors, receptor mechanisms, and drug transporters

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Additional info for Basic and Clinical Pharmacology, 11th Edition (LANGE Basic Science)

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Ligand binding often induces accelerated endocytosis of receptors from the cell surface, followed by the degradation of those receptors (and their bound ligands). When this process occurs at a rate faster than de novo synthesis of receptors, the total number of cell-surface receptors is reduced (down-regulated), and the cell’s responsiveness to ligand is correspondingly diminished. A well-understood example is the EGF receptor tyrosine kinase, which undergoes rapid endocytosis and is trafficked to lysosomes after EGF binding; genetic mutations that interfere with this process cause excessive growth factor–induced cell proliferation and are associated with an increased suscep- CHAPTER 2 Drug Receptors & Pharmacodynamics 23 EGF molecules +EGF –EGF Outside Inside Y Y P P Y Y S~P S ATP ADP FIGURE 2–7 Mechanism of activation of the epidermal growth factor (EGF) receptor, a representative receptor tyrosine kinase.

This constant characterizes the receptor’s affinity for binding the drug in a reciprocal fashion: If the Kd is low, binding affinity is high, and vice versa. The EC50 and Kd may be identical, but need not be, as discussed below. Dose-response data are often presented as a plot of the drug effect (ordinate) against the logarithm of the dose or concentration (abscissa). This mathematical maneuver transforms the hyperbolic curve of Figure 2–1 into a sigmoid curve with a linear midportion (eg, Figure 2–2).

These “gene-active” receptors belong to a protein family that evolved from a common precursor. Dissection of the receptors by recombinant DNA techniques has provided insights into their molecular mechanism. For example, binding of glucocorticoid hormone to its normal receptor protein relieves an inhibitory constraint on the transcription-stimulating activity of the protein. Figure 2–6 schematically depicts the molecular mechanism of glucocorticoid action: In the absence of hormone, the receptor is bound to hsp90, a protein that appears to prevent normal folding of several structural domains of the receptor.

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