Download Aspergillus fumigatus and Aspergillosis by Jean-Paul Latgé, William J. Steinbach PDF
By Jean-Paul Latgé, William J. Steinbach
Invasive and protracted fungal infections became a powerful scientific opponent, and most desirable between them is Aspergillus fumigatus. Aspergillus fumigatus and Aspergillosis assembles chapters from a wide and foreign contingent of specialists within the box to discover each significant point of A. fumigatus and the way it kills such a lot of patients.
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Additional info for Aspergillus fumigatus and Aspergillosis
A dash indicates an insertion or deletion, and a dot indicates a nucleotide that is identical to the nucleotide in the top sequence. , 2007b). , 2007). These targets may display sequence variation by means of two mechanisms: repeat copy number variation (as the result of insertion or deletion of repeats), as well as DNA sequence variation through nucleotide substitutions. One of the main advantages of these targets is the fact that they are analyzed by DNA sequence analysis, rather than through sizing using a high-resolution capillary platform.
These substitutions are in turn the result of nucleic acid substitutions. Analysis of these nucleic acid substitutions are the underlying principle of MLST analysis. Thus, instead of performing phenotypical analyses, DNA sequence analysis of part of a housekeeping gene can now be performed to discriminate between isolates. DNA sequence analysis may even identify nucleotide substitutions that do not affect the mobility of the corresponding proteins. Thus, the number of alleles as determined by DNA sequence analysis (MLST) should be higher than that determined by conventional multilocus enzyme electrophoresis procedures.
Shah, M. Cornet, H. V. Thien, E. Gluckman, G. Bru ¨cker, and J. P. Latge´. 1998. Molecular typing of environmental and patient isolates of Aspergillus fumigatus from various hospital settings. J. Clin. Microbiol. 36:1494–1500. Debeaupuis, J. , J. Sarfati, V. Chazalet, and J. P. Latge´. 1997. Genetic diversity among clinical and environmental isolates of Aspergillus fumigatus. Infect. Immun. 65:3080–3085. , and B. G. Turgeon. 2006. Mating-type structure, evolution, and function in euascomycetes, p.