Download Antimalarial Chemotherapy: Mechanisms of Action, Resistance, by Philip J. Rosenthal PDF


By Philip J. Rosenthal

ISBN-10: 0896036707

ISBN-13: 9780896036703

Philip Rosenthal, MD, and a panel of major malaria specialists drawn from academia, the army, and overseas future health firms survey the newest medical realizing of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the outline of significant new goals. Their survey covers the present prestige of malarial and antimalarial chemotherapy, the appropriate biology and biochemistry of malaria parasites, the antimalarial medicines at the moment to be had, new chemical techniques to chemotherapy, and attainable new goals for chemotherapy. entire and state of the art, Antimalarial Chemotherapy: Mechanisms of motion, Resistance, and New instructions in Drug Discovery sincerely delineates all of the simple and medical study now addressing one of many world's significant unresolved disorder difficulties, paintings that's now powerfully riding the quick speed of antimalarial drug discovery this present day.

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Additional resources for Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery (Infectious Disease)

Sample text

9,12). These seeds were one of the best investments in history. Within a short time, the Dutch plantations of Java were producing 97% of the world’s supply of quinine and had a virtual monopoly, producing in the 1930s about 10 million kilograms of bark a year (Fig. 3). From the mid-19th century to the 1940s, quinine became the standard therapy for intermittent fever throughout the world. Prior to the isolation of quinine, the bark was usually administered as a suspension in wine or spirits to counteract its bitterness.

The first documented drug resistance of human malaria. Int J Parasitol 1996;26:1035–1061. 33. Bruce-Chwatt LJ (ed). Chemotherapy of Malaria. Geneva: World Health Organization, 1986. Transport and Trafficking in Plasmodium-Infected Red Cells 27 3 Transport and Trafficking in Plasmodium-Infected Red Cells Kasturi Haldar and Thomas Akompong INTRODUCTION The organism at the focus of antimalarial chemotherapy is Plasmodium falciparum. It causes the most virulent of human malarias and shows rapidly emerging drug resistance.

9. Russell PF Man’s Mastery of Malaria. London: Oxford University Press, 1955. 10. Taylor N Cinchona in Java; the Story of Quinine. New York: Greenberg, 1945. 11. Smith DC. Quinine and fever: the development of the effective dosage. J Hist Med 1976;31:343–367. 12. Gramiccia G. The Life of Charles Ledger (1818–1905). London: Macmillan, 1988. 13. McHale D. The Cinchona tree. Biologist 1986;33:45–53. 14. Meshnick SR. Why does quinine still work after 350 years of use? Parasitol Today 1997;13:89–90.

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