Download Antibody-Mediated Drug Delivery Systems: Concepts, by Yashwant Pathak, Simon Benita PDF

Organic

By Yashwant Pathak, Simon Benita

ISBN-10: 0470612819

ISBN-13: 9780470612811

Content material:
Chapter 1 Antibody?Mediated Drug supply platforms: basic assessment and functions (pages 1–12): Navdeep Kaur, Karthikeyan Subramani and Yashwant Pathak
Chapter 2 Immunoliposomes for Cardiovascular concentrating on (pages 13–33): Tatyana Levchenko, William Hartner and Vladimir P. Torchilin
Chapter three Antibody?Mediated Drug supply platforms for Breast melanoma Therapeutics (pages 35–55): Leonor Munoz Alcivar and Yashwant Pathak
Chapter four improvement of Immunonconjugates for in Vivo supply: melanoma prognosis, Imaging, and treatment (pages 57–81): Arutselvan Natarajan
Chapter five Mathematical types of Anti?TNF remedies and their Correlation with Tuberculosis (pages 83–104): Simeone Marino, Mohammad Fallahi?Sichani, Jennifer J. Linderman and Denise E. Kirschner
Chapter 6 specified Nanoparticles in Radiotherapy (pages 105–128): Misty Muscarella and Yashwant Pathak
Chapter 7 Electrically?Enhanced supply of gear and Conjugates for melanoma remedy (pages 129–143): Arutselvan Natarajan, Luca Campana and Raji Sundararajan
Chapter eight Characterization of Monoclonal Antibody versions and Glycosylation (pages 145–167): Ting Zheng, Srinivasa Rao, Jeff Rohrer and Chris Pohl
Chapter nine Antibody?Mediated Drug supply method for Lymphatic focusing on therapy (pages 169–190): Fang Wu, Hong Ding and Zhirong Zhang
Chapter 10 equipment for Nanoparticle Conjugation to Monoclonal Antibodies (pages 191–207): Junling Li and Chin ok. Ng
Chapter eleven Single?Use platforms in Animal Cell–Based Bioproduction (pages 209–228): William G. Whitford
Chapter 12 Immunoliposomes for particular Drug supply (pages 229–266): Manuela Calin
Chapter thirteen Gene remedy focusing on Kidney illnesses: Routes and cars (pages 267–277): Yoshitaka Isaka, Yoshitsugu Takabatake and Hiromi Rakugi
Chapter 14 Detection of Antibodies to Poly(Ethylene Glycol) Polymers utilizing Double?Antigen?Bridging Immunogenicity ELISA (pages 279–290): Yijuan Liu, Helen Reidler, Jing Pan, David Milunic, Dujie Qin, Dave Chen, Yli Remo Vallejo and Ray Yin
Chapter 15 Antibodies in Nanomedicine and Microimaging tools (pages 291–349): Rakesh Sharma
Chapter sixteen equipment for Polymeric Nanoparticle Conjugation to Monoclonal Antibodies (pages 351–363): Uyen Minh Le, Hieu Tran and Yashwant Pathak
Chapter 17 Plant?Derived Antibodies for educational, commercial, and healing purposes (pages 365–381): Slavko Komarnytsky and Nikolai Borisjuk
Chapter 18 Monoclonal Antibodies as Biopharmaceuticals (pages 383–389): Girish J. Kotwal
Chapter 19 Pulmonary concentrating on of Nanoparticles and Monoclonal Antibodies (pages 391–405): Weiyuan Chang
Chapter 20 Antibody?Mediated Arthritis and New healing Avenues (pages 407–426): Kutty Selva Nandakumar
Chapter 21 Immunonanoparticles for Nuclear Imaging and Radiotherapy (pages 427–456): Oren Giladi and Simon Benita
Chapter 22 Monoclonal Antibodies within the therapy of bronchial asthma (pages 457–472): Glenn J. Whelan

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Extra info for Antibody-Mediated Drug Delivery Systems: Concepts, Technology, and Applications

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The internalization of [125 I]immunoliposomes by human endothelial cells, followed by comparing total liposomal 125 I radioactivity associated with cells, and cell surface–adsorbed liposomes was revealed using avidin–peroxidase. Initial immunoliposome binding to the cells at 4◦ C and subsequent endocytosis at 37◦ C resulted in the internalization of about 30% of the cell-associated liposomes and thus would permit intracellular delivery of pharmacologically active substances. Endothelial cell adhesion molecules, expressed in response to inflammatory signals to then mediate recruitment of leukocytes to sites of inflammation, appear to be excellent targets for drug delivery systems.

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Additionally, certain intracellular proteins, including the components of cytoskeleton (myosin, vimentin), can become exposed to the surroundings through these holes. Thus, appropriately labeled antibodies against intracellular cytoskeletal antigens could be used to reveal cell membrane lesions. Moreover, if coupled to liposomes, such antibodies should deliver phospholipid vesicles to an affected cell’s surface and anchor (plug) them directly (over) into the holes. This suggestion was tried with antibody-directed liposomes to cytoskeletal antigens to prevent hypoxia-induced release of intracellular contents and subsequent cell death by sealing (plugging) the membrane lesions.

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