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By Richard V Heinzelman; American Chemical Society. Division of Medicinal Chemistry

ISBN-10: 0120405075

ISBN-13: 9780120405077

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Drugged” state. - Several reports described effects of t h e methylxanthines and amantadine on b r a i n monoamine m e t a b o l i s m which may be involved i n t h e i r pharmacological actions. ’o6 The i n c r e a s e i n c y c l i c AMP produced by these drugs, u s u a l l y a t t r i b u t e d t o i n h i b i t i o n of phosphodiesterase, could be I n mice due t o stimulation of adenyl cyclase by t h e released NE. ”* e f f e c t s of amantadine have stimulated s t u d i e s o f i t s c e n t r a l actions.

Pharmacol. 2l, 497 (1971). 15. J. B. Hester, A. D. Rudzik and B. V. Kamdar, J. Med. Chem. 1078 8. m, 16. 14, ( 19711 A. D. Rudzik, J. B. Hester and W. (1971) F r i i s , The Pharmacologist, 12,205 17. T. M. I t i l , B. S a l e t u , J. Marasa and A. N. Mucciardi, D i s . Nerv. S y s t . , i n press. 18. R. Nakajima, Y. S a j i , S. Chiba and Y. Nagawa, J. Takeda Res. Lab 3, 153 (1970). 19. Chem. Drug. 192,228 (1970). 20. Janssen, C. J. E. Niemegiers, K. H. L. Schellekens and F. M. L e n a e r t s , Arzneimittel - Forsch.

271, 221 (1971). 2, 2, 2 m, 2, H, z, 2, 30 Sect. 1 - CNS Agents E n g e l h a r d t , Ed. 103. G. A. Clay, A. K. Cho and M. Roberfroid, Biochem. , g,1821 (1971). 176 (1971). 104. H. C. Rbiger and E. G. McGeer, Eur. J. , 105. R. T. H i l l , Abstracts, 7th Middle Atlantic Regional Meeting Amer. Chem. , Feb. 14-17, 1972, 16, p. B. B. B. 59. A. Berkowitz, J. H. Tarver and S. Spector, Eur. J. , 2, 64 (1970). Waldeck, J. Pham. , 23, 824 (1971). A. Berkowitz and S. Spector, Eur. J. h a m c o l . , 322 (1971).

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