Download Animal Models in Toxicology 2nd Edition (Drug and Chemical by C. Gad Shayne PDF

Toxicology

By C. Gad Shayne

ISBN-10: 0824754077

ISBN-13: 9780824754075

Reflecting greater than a decade’s worthy of adjustments, Animal versions in Toxicology, moment version is a realistic consultant to the typical statistical difficulties encountered in toxicology and the methodologies which are to be had to unravel them. The booklet provides a old overview of using animal types and an summary of large issues of metabolism and relevance utilized in toxicology. person chapters masking the 8 significant species utilized in toxicology and experimental biology shape the center of the publication. With contributions from specialists in toxicology, toxicological pathology, and species-specific metabolism, every one of those chapters supply a good introductory “course” besides advice to the literature for extra targeted knowing. The ebook is going directly to make the case for a number of species no longer universal for protection evaluate reports yet that may supply precious replacement versions for a few particular endpoints. The bankruptcy authors speak about distinct issues concerning theevaluation and interpretation of the medical pathology of the 8 significant version species in addition to tips on how to opt for a version species and the way to extrapolate the consequences to people. They aspect power pitfalls and events that reason both human or version to be considerably extra delicate than the opposite or completely inappropriate to one another. The booklet concludes with an summary of the more and more complicated legislation and rules that govern how laboratory animals are received, maintained, and applied, and an appendix that gives a brief advisor to advertisement resources of laboratory animals.

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Guengerich, F. (1988). Minireview; cytochromes P-450. Comp. Biochem. Physiol. 89C, 1–4. , and Dahl, A. (1983). Cytochrome P-450 dependent monooxygenase activity in nasal membranes. Drug Metab. Dispos. 11, 275–276. , and Vainio, H. (1973). Interspecies variations in small intestinal and hepatic drug hydroxylation and glucuronidation. Acta Pharmacol. Toxicol. 33, 57–64. , and Vainio, H. (1976). Effect of administration route on DDT acute toxicity and on drug biotransformation in various rodents. Arch.

Pharmacol. 67, 430–441. Guengerich, F. (1988). Minireview; cytochromes P-450. Comp. Biochem. Physiol. 89C, 1–4. , and Dahl, A. (1983). Cytochrome P-450 dependent monooxygenase activity in nasal membranes. Drug Metab. Dispos. 11, 275–276. , and Vainio, H. (1973). Interspecies variations in small intestinal and hepatic drug hydroxylation and glucuronidation. Acta Pharmacol. Toxicol. 33, 57–64. , and Vainio, H. (1976). Effect of administration route on DDT acute toxicity and on drug biotransformation in various rodents.

Zakim and D. Vessay, 95–159. New York: Wiley Interscience. , and Gandolfi, A. (1986). Biotransformation of toxicants. In Casarett and Doull’s toxicology: The basic sciences of poisons, eds. C. Klaassen, M. Amdur, and J. Doull, 64–98. New York: Macmillan. , and Timbrell, J. (1974). Factors affecting the metabolism of phenacetin: I. Influence of dose, chronic dosage, route of administration and species on the metabolism of [1-14C-acetyl]phenacetin. Xenobiotica. 8, 489–501. , and Emerole, G. (1983).

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