Download An introduction to immunotoxicology by Jacques Descotes PDF

Toxicology

By Jacques Descotes

ISBN-10: 074840306X

ISBN-13: 9780748403066

Lyon-RTH Laennec college of drugs, France. advent to key immunotoxicological matters. Considers the well-being results of immunotoxicity and addresses the cutting-edge equipment used to observe and evaluation unforeseen immunotoxic results of xenobiotics, either preclinically and clinically. For undergraduate and graduate scholars. Hardcover, softcover additionally on hand.

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Overall, the adverse consequences of immunostimulation on human health have been less extensively investigated than those of immunosuppression, because immunosuppression has been an issue of primary concern for immunotoxicologists during the past 20 years, but also because potent immunostimulating agents, such as the recombinant cytokines interferon␣ and IL-2, were introduced into the clinical setting only recently. Even though early medicinal products proposed for use as immunostimulants, such as levamisole, Corynebacterium parvum and thymic hormones, did not prove to exert marked therapeutic activity (Smalley and Oldham, 1984), adverse effects in some patients treated with these medicinal products were described more than ten years ago (Descotes, 1985a; Davies, 1986), and the clinical experience gained with the use of the most recent recombinant cytokines to treat human patients, largely confirmed these early reports.

1993) Respiratory infections in immunocompromised patients. Immunol Allergy Clin. N. , 13, 193–204. D. (1995) Viral complications after transplantation. J. Antimicrob. , 36, Suppl. B, 91–106. HARWOOD, J. (1989) Lessons from the seal epidemic. New Scientist, 18 February, 38–42. M. A. (1995) Immunosuppression associated lymphoproliferative disorders in rheumatic patients. Leuk. , 16, 363–368. H. and FINLAND, M. (1953) Adrenocortical hormones in infection and immunity. Annu. Rev. , 7, 361–388. , PETO, J.

G. Pseudomonas aeruginosa) and fungi (Candida, Nocardia, Aspergillus) are less common. The digestive tract is the first line of defence against oral pathogens. Any dysfunction of specific and non-specific defence mechanisms can result in more frequent and/or more severe gastrointestinal infections with often atypical clinical features and prolonged or recurring outcome (Bodey and Fainstein, 1986). g. chronic diarrhoeal syndrome) may predominate in some patients. Associated risk factors, such as atrophy of the gastric mucosa, increased gastric acid secretion, and alterations of the intestinal flora, contribute to the development of gastrointestinal infections in immunocompromised patients.

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