Download Alternatives to Animal Testing by R. E. Hester, R. M. Harrison PDF


By R. E. Hester, R. M. Harrison

ISBN-10: 0854042113

ISBN-13: 9780854042111

Animal experimentation has lengthy been a arguable factor, with impassioned arguments on each side of the controversy. more and more it has turn into extra expedient and possible to advance new tools that steer clear of using animals. there's contract on each side that relief and refinement of experiments on animals can be a huge target for the industries involved.

Alternatives to Animal checking out, written via major specialists within the box, discusses the problems concerned and methods that may be taken. subject matters comprise: the protection overview of chemical compounds; foreign validation and obstacles to the validation of different checks; in vitro trying out for endocrine disruptors; clever methods to security overview of chemical substances; replacement exams and the regulatory framework.

The publication presents an updated dialogue of the present country of improvement of possible choices to animal checking out and is perfect for pros and teachers within the box. it is going to even be of use for graduate scholars wishing to pursue a profession within the pharmaceutical and cosmetics industries.

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I. (1963). Toxicity of higher saturated monovalent alcohols (hexanol, heptanol, octanol, nonanol, and decanol). Toksikol. Novykh Prom. Khim. Veshchestv no. 5, p. 51. 39 A L C O H O L C-8 Synonyms: 1-Octanol; w-octyl alcohol. Structure: C H 3 - [ C H 2 ] 6 - C H 2 O H . Description and physical properties. EOA Spec. no. 166. Occurrence: Found in several citrus oils and at least ten other natural sources (Gildemeister & Hoffman, 1960). Preparation: By sodium reduction or high-pressure catalytic hydrogénation of the esters of the naturally occuring caprylic acid, or by oligomerization of ethylene using aluminium alkyl technology.

III. T h e maximization test. A procedure for screening and rating contact sensitizers. / . invest. Derm. 4 7 , 393. Kligman, A . M . (1972). Report to R I F M , 2 M a y . Peterson, H . R. & Hall, A . (1946). Dermal irritating properties o f perfume materials. Drug Cosmet. Ind. 58, 113. Treon, J. F. (1963). Alcohols. In Industrial Hygiene and Toxicology. 2nd ed. Edited by F. A . Patty, Vol. II, p. 1464. Interscience Publishers, N e w York. 42 A L C O H O L C-10 Synonyms: 1-Decanol; w-decyl alcohol.

Hausen, Β. M. & Schulz, Κ. Η. (1975). Experimental studies on the identification of chrysanthemum allergies. Contact Dermatitis 1, 244. Hjorth, N. (1970). Active sensitization with alantolactone. Contact Dermatitis Newsl. 4. 175. Kligman, A. M. (1966). The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. invest. Derm. 47, 393. Kligman, A. M. (1975). Report to RIFM, 10 June. Kligman, A. M. & Epstein, W. (1975).

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