Download Aging, Immunity, and Infection (Infectious Disease) by Joseph F. Albright PDF


By Joseph F. Albright

ISBN-10: 0896036448

ISBN-13: 9780896036444

Fashionable immunogerontologists assessment the foremost good points and capabilities of the immune approach which are probably, or recognized, to be considerably altered through getting older, and supply insightful analyses of the results for these getting older topics who needs to focus on an infection. issues of distinct curiosity comprise the demographics and theories of immunosenescence, the slow breakdown of resistance to an infection within the elderly, and the consequences of getting older on chosen mechanisms of either innate and adaptive immunity to infections. The Albrights additionally clarify how advances could be made in figuring out the fundamental biology, the more recent equipment of remedy and prevention, and the overview of such provocative rules as lifespan extension and dietary intervention to hold up immunosenescence.

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Extra info for Aging, Immunity, and Infection (Infectious Disease)

Sample text

Some adhesins fail, however, as hemagglutinins (perhaps because the saccharide moieties that they recognize on erythrocytes are inaccessible) but do interact with cells of the intestinal tract. Intestinal mucous contains numerous, potentially inhibitory saccharide moieties that may block bacterial adherence. Whether or not this occurs depends on a number of factors including the quantity and rate of formation of mucous. The wide variety of glycoconjugates with which bacterial lectins interact is shown in Table 2-4.

5% with influenza A or B, and 7% with respiratory syncytial virus, and the remainder with other agents. In the case of urinary tract infections (UTIs) in the elderly, two independent studies, separated by an interval of 12 yr, gave very similar results. One study was performed in Sweden in 1986 on a group of 1966 subjects having a mean Aging and Altered Resistance to Infection 21 Table 2-2 Pathogens Found Frequently in Elderly Subjects with Respiratory or Urinary Tract Infections Organ system Respiratory tract (upper and lower) Pathogen found frequently Bacteria Streptococcus pneumoniae Hemophilus influenza Legionella pneumophila Chlamidia pneumoniae Viruses Rhinoviruses Coronaviruses Influenza Respiratory syncytial Urinary tract Bacteria Escherichia coli Proteus Klebsiella Pseudomonas aeruginosa Enterococci age of 70 years (4).

Only in the last decade have these various events been elucidated. Most of the studies have been done in model, in vitro systems or in young, experimental animals. At present, little is known about how the various interactive events might differ in the case of mucosal surfaces of aged hosts. There follows a series of brief descriptions of the interactive events as currently understood. Bacterial Attachment The attachment to host cells is required for bacterial proliferation, colony formation, invasion of host cells, or translocation across endothelial or epithelial host cell layers.

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