Download Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, PDF


By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

ISBN-10: 146137720X

ISBN-13: 9781461377207

This quantity represents the complaints of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park hotel and hotel in Asheville, North Carolina, October 13-17, 1996. we're overjoyed to offer this quantity to the ophthalmic neighborhood, specially people with an important curiosity in ocular toxicol­ ogy. The 5th Congress was once constructed round topics with regards to ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt matters in terms of using substitute equipment for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to diversified animal types. the result of this congress, embodied during this quantity, is a contribution to the methodologies presently hired or lower than improvement and to numerous drug or actual results on varied ocular tissues. whereas the focal point of this court cases is on ocular results of substances or different fabrics, a few of the contributions take care of subject matters that experience a much wider curiosity. The workshop about the use of other version platforms and the alternative of the easiest animal version for drug checking out covers quite a lot of pursuits that ex­ has a tendency a ways past particular ocular results. this is often very true within the region of other equipment and within the selection of the simplest animal version for exam of alternative disorder entities.

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All these methods suffer from the risk of auto-oxidation of the released thiols as well as possible incomplete removal of added NaBH4 or thiol protecting agents. To circumvent the above shortcomings we have developed a new method by using a strong oxidant (performic acid) to treat the lens homogenate, thereby opening the disulfide bridges and releasing the non-protein thiols as stable sulfonic acid products. The unused 30 M. F. Lou performic acid is inactivated with excess amount of water and then removed by lyophilization.

Since it has been shown by Davis et al 5 and Conners et a1. 4 •5 that contact lenses activate the corneal epithelial cytochrome P450 pathway to produce both 12(R)HETE and 12(R)HETrE, understanding the diffusional and/or transport characteristics and metabolism of 12(R)HETE in the cornea is of clinical importance for individuals wearing contact lenses. This study has shown that 12(R)HETE and its metabolites preferentially remain in shor1 term cellular changes (minutes & hours) singular event - low osmolality - ouab n I cellular ..

First, there was no reliable method to differentiate and quantify the protein-thiol mixed disulfides, thus the reported PSSG value varied considerably. Second, interest in the protein-thiol mixed disulfide in cataracts was diminished after negative results in an osmotic induced cataract model were reported suggesting that the protein thiolation process did not appear to play an essential role in cataractogenesis. ls However, the findings from our laboratory have rekindled interest in this field.

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